Research and Studies

As more and more (long overdue) attention is paid within the scientific community to understanding women’s health, our scientific understanding of healthy vaginal physiology has evolved significantly in the past decade. Alarmingly, most of the commercially available vaginal products utilize formulas that were invented more than a decade ago, before the vaginal ecosystem was well studied.

And, almost no products have been designed to support or optimize the complexity of the woman’s vaginal ecosystem or even to acknowledge the fundamental presence of this system. IsoLove Vaginal Gels are revolutionary in that they are isotonic, paraben-free, and pH-matched to vaginal tissues – providing effective solutions to your most sensitive issues.

The following scientific research articles and references were used in developing the IsoLove products, as well as the information provided on this site.

Shen, Ruizhong, et al. Early HIV-1 Target Cells in Human Vaginal and Ectocervical Mucosa. Am J Reprod Immunol. 2011 March; 65(3): 261-267.

World Health Organization Advisory Note. Use and procurement of additional lubricants for male and female condoms. WHO/UNFPA/FHI360, 2012.

Adriaens E and Remon JP. Mucuosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucuosal irritation assay. Sexually Transmitted Diseases, 200, 35:512-516.

Fuchs EJ, Lee LA, Torbenson MS, et al. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. Journal of Infections Disease, 2007; 195: 703-10.

Martin Jenny L and Sten H Vermund. Vaginal Douching: Evidence for Risks or Benefits to Women’s Health. Epidemiol Rev. 2002; 24(2): 109-124.

Cottrell BH. An updated review of evidence to discourage douching. MCN Am J Matern Child Nurs. 2010 Mar-Apr; 35(2):1027-7.

Branch, et al. Vaginal douching and racial/ethnic disparities in phthalates exposures among reproductive-aged women: National Health and Nutrition Examination Survey 2001-2004. Environmental Health, 2015 1-8. Office on Women’s Health, US Department of Health and Human Services. Douching fact sheet.


Van de Wiljgert JH, et al. The vaginal microbiota: what have we learned after a decade of molecular characterization? PLos One. 2014 August 22; 9(8):e105998.

Mendling W.Vaginal Microbiota. Adv Exp Med Biol. 2016;902:83-93.

Dactu R. Characterization of the vaginal microflora in health and disease. Dan Med J. 2014 Apr;61(4):B4830.

Critchfield AS, et al. Cervical mucus properties stratify risk for preterm birth. PLoS One. 2013 Aug 1; 8(8)L e69528

Anderson DJ, et al. The Structure of the Human Vaginal Stratum Corneum and its Role In Immune Defense. Am J Reprod Immunol. 2014 june; 7196): 618-623.

Mirmonsef P et al. An exploratory comparison of vaginal glycogen and Lactobacillus levels in pre-and post-menopausal women. Menopause. 2015 July; 22(7): 702-709.

Mirmonsef P et al. Free glycogen in vaginal fluids is associated with Lactobacillus colonization and ow vaginal pH. PLoS One 2014 Jul 17:9(7); e102467

Spear GT. Effect of pH on Cleavage of Glycogen by Vaginal Enzymes. PLoS One. 2015; 10(7): e0132646

Spear GT. Human alpha-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus. J Infect Dis. 2014 Oct 1;210(7):1019-28

Nasioudis D, et al. alpha-Amylase in Vaginal Fluid: Association With Conditions Favorable to Dominance of Lactobacillius. Reprod Sci. 2015 Nov; 22(11):1393-8.

Hickey RJ, et al. Understanding vaginal microbiome complexity from an ecological perspective. Transl Res 2012 Oct; 160(4): 267-82.